Peptide profile
CJC-1295
Long-acting GHRH analog for GH elevation · also known as CJC-1295 DAC, Drug Affinity Complex-1295, Modified GRF(1-29)
Compare CJC-1295 with other peptides →Summary
A long-acting GHRH analog that extends the half-life of endogenous growth hormone releasing hormone, producing sustained elevation of GH and IGF-1.
- Typical dose
- 1-2 mg once weekly (DAC form)
- Half-life
- 6-8 days (DAC form)
- Route
- Subcutaneous, Intramuscular
- Cycle length
- 8-12 weeks
Mechanism
How it works
Binds to albumin in the bloodstream via a Drug Affinity Complex (DAC) technology, extending the active half-life from minutes to days while continuously stimulating pituitary GH release.
Reported in research
Benefits
- Sustained elevation of growth hormone and IGF-1
- Improved lean body mass and fat metabolism
- Enhanced recovery and cellular repair
- Potential longevity and anti-aging effects via IGF-1 signaling
Context, not a prescription
Dosing
- Typical range
- 1-2 mg once weekly (DAC form) (Subcutaneous, Intramuscular)
- Cycle length
- 8-12 weeks
- Half-life
- 6-8 days (DAC form)
Safety
Side effects & contraindications
Possible side effects
- Water retention
- Fatigue or lethargy (transient)
- Flushing or tingling shortly after injection
- Potential IGF-1 elevation above physiological range with high doses
Contraindications
- Active malignancy
- Diabetic retinopathy or uncontrolled diabetes
- Acromegaly or existing GH excess
- Pregnancy
Research information, not medical advice. Always consult a licensed clinician before considering any peptide.
In depth
Full profile
What it does
You heal faster, sleep better, keep lean muscle, and lose body fat.
How it works
CJC-1295 is like a dam on a river. It makes your natural growth hormone bursts bigger instead of making new ones.
It connects to special spots in your brain's pituitary gland. This tells your body to make and release growth hormone.
What to expect
Growth hormone goes up in a few hours. You feel changes by 2-3 weeks.
- Weeks 1-2: You sleep better.
- Weeks 3-4: You bounce back from workouts faster.
- Weeks 6-8: Your body shape starts to change.
Good to know
- Take breaks. Rest as long as you use it.
- Keep an eye on your blood sugar.
- Pair it with GHRP for better results.
Staying safe
- A bump or redness where you got the shot
- Holding a little extra water
- Headache
Avoid if you have:
- People who have cancer right now
- People with very bad diabetes
- People with serious eye problems
Mechanism of action
Long-acting analog of GHRH that increases GH pulse amplitude, leading to elevated IGF-1 and anabolic activity.
Binds to GHRH receptors on pituitary somatotrophs to stimulate GH synthesis and release.
Pharmacodynamics
GH elevation within hours; noticeable effects by 2-3 weeks.
Improved recovery, better sleep, lean mass retention, reduced body fat.
Timeline
- Weeks 1-2: Improved sleep quality.
- Weeks 3-4: Enhanced exercise recovery.
- Weeks 6-8: Noticeable body composition changes.
Comparisons
- CJC-1295 — effectiveness Moderate, safety Good, cost $$, Medium to use
- Sermorelin — effectiveness Low, safety Good, cost $$, Medium to use
Adverse effects
Common:
- Injection site reaction
- Mild water retention
- Headache
Rare:
- Carpal tunnel symptoms
- Joint pain
- Insulin resistance (prolonged use)
Contraindications & risk mitigation
Contraindicated in:
- Active cancer
- Severe diabetes
- Proliferative retinopathy
- Cycle with breaks (off-time equals on-time)
- Monitor blood glucose
- Stack with GHRP for synergy
Qué hace
Te recuperas más rápido, duermes mejor, mantienes el músculo magro y pierdes grasa corporal.
Cómo funciona
El CJC-1295 es como una presa en un río. Hace que tus picos naturales de hormona del crecimiento sean más grandes en lugar de crear nuevos.
Se conecta a puntos especiales en la glándula pituitaria de tu cerebro. Esto le indica a tu cuerpo que produzca y libere hormona del crecimiento.
Qué esperar
La hormona del crecimiento aumenta en unas horas. Notas los cambios en 2-3 semanas.
- Semanas 1-2: Duermes mejor.
- Semanas 3-4: Te recuperas más rápido de los entrenamientos.
- Semanas 6-8: La forma de tu cuerpo empieza a cambiar.
Bueno saber
- Toma descansos. Descansa tanto como lo uses.
- Monitorea tu azúcar en sangre.
- Combínalo con GHRP para mejores resultados.
Manteniéndose seguro
- Un bulto o enrojecimiento en el lugar de la inyección
- Retener un poco más de agua
- Dolor de cabeza
Evitar si tienes:
- Personas que tienen cáncer actualmente
- Personas con diabetes muy severa
- Personas con problemas oculares graves
Mecanismo de acción
Análogo de GHRH de acción prolongada que aumenta la amplitud de los pulsos de GH, lo que conduce a una elevación del IGF-1 y a una actividad anabólica.
Se une a los receptores de GHRH en los somatotrofos pituitarios para estimular la síntesis y liberación de GH.
Farmacodinamia
Elevación de la GH en horas; efectos notables a las 2-3 semanas.
Recuperación mejorada, mejor sueño, retención de masa magra, reducción de grasa corporal.
Cronología
- Semanas 1-2: Mejora de la calidad del sueño.
- Semanas 3-4: Recuperación mejorada tras el ejercicio.
- Semanas 6-8: Cambios notables en la composición corporal.
Comparaciones
- CJC-1295 — efectividad Moderada, seguridad Buena, costo $$, Media de usar
- Sermorelin — efectividad Baja, seguridad Buena, costo $$, Media de usar
Efectos adversos
Comunes:
- Reacción en el sitio de inyección
- Retención de líquidos leve
- Dolor de cabeza
Raros:
- Síntomas de síndrome del túnel carpiano
- Dolor articular
- Resistencia a la insulina (uso prolongado)
Contraindicaciones y mitigación de riesgos
Contraindicado en:
- Cáncer activo
- Diabetes grave
- Retinopatía proliferativa
- Ciclos con descansos (tiempo de descanso igual al tiempo de uso)
- Monitorear la glucosa en sangre
- Combinar con GHRP para sinergia
Reference data
Specifications
- Molecular formula
- C152H252N44O42
- Molecular weight
- 3367.9 g/mol
- Half-life
- 6-8 days (DAC form)
- Route
- Subcutaneous, Intramuscular
- Cycle length
- 8-12 weeks
- Storage
- Lyophilized: stable at room temperature short-term. Reconstituted: refrigerate at 2-8 C, use within 30 days.
- Legal status
- Research compound; not approved by FDA or EMA for general human use.
FAQ
Common questions
CJC-1295 with DAC vs no DAC?
DAC version has longer half-life (6-8 days). Most prefer no DAC to mimic natural GH pulses.
Should CJC-1295 be stacked?
Yes, commonly stacked with ipamorelin or GHRP-2 for synergistic GH release.
What is the evidence level?
This compound is classified as Limited human data. Some human data exists but trials are small, short-term, or not yet replicated.
Research
Research & sources
Current evidence for CJC-1295 is rated as Limited human data. Limited human data is available.
- 1. CJC-1295 pharmacokinetics (2004) — DOI:10.1210/jc.2004-0981
- 2. GHRH analogs review (2006) — DOI:10.1016/j.mce.2006.08.006
- 3. Jetté et al. — CJC-1295 pharmacokinetics and GH release in healthy adults
- 4. Alba et al. — Long-acting GHRH analogs and IGF-1
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