Peptide profile
Follistatin-344
Myostatin antagonist for muscle hyperplasia
Compare Follistatin-344 with other peptides →Summary
Helps build a lot of muscle by blocking your body's muscle brake.
- Typical dose
- 100-300mcg 1-2x weekly
- Route
- Subcutaneous
- Cycle length
- 4-6 weeks
- Evidence
- Anecdotal
Mechanism
How it works
Follistatin is like a sponge for myostatin — it soaks up the body's natural brake pedal on muscle growth, allowing muscles to grow unchecked.
Follistatin binds to myostatin (GDF-8) with high affinity, preventing myostatin from activating its receptor on muscle cells.
Reported in research
Benefits
- Turns off your body's muscle brake so muscles can grow
- Might grow a huge amount of new muscle
- Made muscles much bigger in animal tests
Context, not a prescription
Dosing
- Typical range
- 100-300mcg 1-2x weekly (Subcutaneous)
- Cycle length
- 4-6 weeks
Safety
Side effects & contraindications
Possible side effects
- Injection site inflammation
- Fatigue
- Joint pain
- Tendon rupture (theoretical)
- Cardiac hypertrophy (prolonged use)
- Severe immune reaction
Contraindications
- Pregnancy or breastfeeding
- History of tendon rupture
- Cardiac disease
- Active cancer
Research information, not medical advice. Always consult a licensed clinician before considering any peptide.
In depth
Full profile
What it does
It might grow a lot of muscle. But it is risky and we know very little about it in people.
How it works
Follistatin is like a sponge that soaks up myostatin. Myostatin is your body's brake pedal on muscle growth. With it gone, muscles can grow without stopping.
It sticks to myostatin and similar signals and holds them. This stops them from switching on the muscle brake.
What to expect
It may take weeks to see anything. The full effect comes by 4-6 weeks.
- Weeks 1-2: Small changes. You might feel tired.
- Weeks 3-4: Your muscles slowly look fuller.
- Weeks 4-6: The biggest muscle growth happens. Stop after this.
Good to know
- Use it for a very short time (4 weeks at most)
- Use the smallest amount that works
- Watch closely for any heart problems
- Don't mix it with other muscle brake blockers
Staying safe
- Swelling where you got the shot
- Feeling tired
- Sore joints
Avoid if you have:
- Women who are pregnant or breastfeeding
- People who have torn a tendon before
- People with heart problems
- People who have cancer right now
Mechanism of action
Follistatin binds to myostatin (GDF-8) with high affinity, preventing myostatin from activating its receptor on muscle cells.
Neutralizes myostatin and activins by binding directly to them, preventing ActRIIB receptor activation.
Pharmacodynamics
Effects may take weeks to appear; full effect by 4-6 weeks.
Potential dramatic muscle growth, but high risk profile with minimal human safety data.
Timeline
- Weeks 1-2: Subtle changes; potential fatigue.
- Weeks 3-4: Progressive muscle fullness.
- Weeks 4-6: Maximum muscle growth effect — discontinue after.
Comparisons
- Follistatin-344 — effectiveness Unknown, safety Poor, cost $$$, Hard to use
- ACVR2B-Fc — effectiveness Unknown, safety Poor, cost $$$, Hard to use
Adverse effects
Common:
- Injection site inflammation
- Fatigue
- Joint pain
Rare:
- Tendon rupture (theoretical)
- Cardiac hypertrophy (prolonged use)
- Severe immune reaction
Contraindications & risk mitigation
Contraindicated in:
- Pregnancy or breastfeeding
- History of tendon rupture
- Cardiac disease
- Active cancer
- Extremely short cycles (4 weeks max)
- Lowest effective dose
- Monitor for cardiac symptoms
- Avoid stacking with other myostatin inhibitors
Qué hace
Podría generar mucho músculo. Pero es arriesgado y sabemos muy poco sobre su uso en personas.
Cómo funciona
La follistatina es como una esponja que absorbe la miostatina. La miostatina es el pedal de freno de tu cuerpo para el crecimiento muscular. Al eliminarla, los músculos pueden crecer sin parar.
Se une a la miostatina y señales similares, manteniéndolas bloqueadas. Esto evita que activen el freno muscular.
Qué esperar
Puede tardar semanas en notarse algo. El efecto completo se ve en 4-6 semanas.
- Semanas 1-2: Cambios pequeños. Podrías sentirte cansado.
- Semanas 3-4: Tus músculos se ven más llenos poco a poco.
- Semanas 4-6: Se produce el mayor crecimiento muscular. Deja de usarlo después de esto.
Bueno saber
- Úsalo por un tiempo muy corto (máximo 4 semanas)
- Usa la cantidad mínima que funcione
- Vigila de cerca cualquier problema cardíaco
- No lo combines con otros bloqueadores del freno muscular
Manteniéndose seguro
- Hinchazón en el lugar de la inyección
- Sensación de cansancio
- Dolor en las articulaciones
Evitar si tienes:
- Mujeres embarazadas o en lactancia
- Personas que han tenido una rotura de tendón anteriormente
- Personas con problemas cardíacos
- Personas que tienen cáncer actualmente
Mecanismo de acción
La follistatina se une a la miostatina (GDF-8) con alta afinidad, impidiendo que la miostatina active su receptor en las células musculares.
Neutraliza la miostatina y las activinas uniéndose directamente a ellas, lo que impide la activación del receptor ActRIIB.
Farmacodinamia
Los efectos pueden tardar semanas en aparecer; el efecto completo se alcanza en 4-6 semanas.
Potencial crecimiento muscular drástico, pero con un perfil de riesgo alto y datos mínimos de seguridad en humanos.
Cronología
- Semanas 1-2: Cambios sutiles; posible fatiga.
- Semanas 3-4: Plenitud muscular progresiva.
- Semanas 4-6: Efecto máximo de crecimiento muscular: suspender después de este periodo.
Comparaciones
- Follistatina-344 — efectividad Desconocida, seguridad Baja, costo $$$, Difícil de usar
- ACVR2B-Fc — efectividad Desconocida, seguridad Baja, costo $$$, Difícil de usar
Efectos adversos
Comunes:
- Inflamación en el sitio de inyección
- Fatiga
- Dolor articular
Raros:
- Rotura de tendón (teórica)
- Hipertrofia cardíaca (uso prolongado)
- Reacción inmunitaria grave
Contraindicaciones y mitigación de riesgos
Contraindicado en:
- Embarazo o lactancia
- Antecedentes de rotura de tendón
- Enfermedad cardíaca
- Cáncer activo
- Ciclos extremadamente cortos (máximo 4 semanas)
- Dosis efectiva más baja
- Monitorear síntomas cardíacos
- Evitar combinar con otros inhibidores de la miostatina
Reference data
Specifications
- Route
- Subcutaneous
- Cycle length
- 4-6 weeks
FAQ
Common questions
Is follistatin safe for humans?
No, human safety data is extremely limited. Notable risks include cardiac hypertrophy and tendon rupture.
What is the difference between follistatin-344 and follistatin-315?
Follistatin-344 is the naturally occurring human form; follistatin-315 has a different heparin-binding domain affecting tissue distribution.
What is the evidence level?
This compound is classified as Anecdotal. Evidence relies primarily on self-reported user experiences. Controlled studies are lacking.
Research
Research & sources
Current evidence for Follistatin-344 is rated as Anecdotal. No controlled clinical research is available.
- 1. Follistatin and myostatin (2002) — DOI:10.1016/S1097-2765(02)00717-9
- 2. Myostatin inhibition risks (2012) — DOI:10.1016/j.cmet.2012.10.013
- 3. Follistatin and myostatin (2002)
- 4. Myostatin inhibition risks (2012)