Peptide profile
NAPVSIPQ (ADNP fragment)
Active fragment of neuroprotective protein ADNP
Compare NAPVSIPQ (ADNP fragment) with other peptides →Summary
A tiny protein piece that helps protect brain cells.
- Typical dose
- 10-25mg 1-2x daily intranasal
- Route
- Nasal
- Cycle length
- 30-90 days
- Evidence
- Anecdotal
Mechanism
How it works
This peptide acts like a duct tape for damaged brain cells — it helps hold together the internal skeleton of neurons that degenerates in Alzheimer's and other tauopathies.
NAPVSIPQ is the core active motif of ADNP (activity-dependent neuroprotective protein), which binds to microtubules and interacts with tau to maintain cytoskeletal integrity.
Reported in research
Benefits
- Helps keep brain cells from dying
- Helped animals think better in studies
- Lowers harmful stress inside cells
- Helps brain cells make stronger connections
Context, not a prescription
Dosing
- Typical range
- 10-25mg 1-2x daily intranasal (Nasal)
- Cycle length
- 30-90 days
Safety
Side effects & contraindications
Possible side effects
- Nasal irritation
- Mild headache
- Unknown (limited human data)
Contraindications
- Pregnancy or breastfeeding
- Known hypersensitivity
Research information, not medical advice. Always consult a licensed clinician before considering any peptide.
In depth
Full profile
What it does
It might protect thinking and helped animals a little in studies.
How it works
Think of this peptide like duct tape for hurt brain cells. It helps hold together the inside frame of brain cells that falls apart in diseases like Alzheimer's.
It works with tiny parts inside brain cells and a protein called tau. It helps keep cells healthy and helps them grow new branches.
What to expect
It protects the brain slowly over weeks. You won't feel anything right away.
- Weeks 4-6: Your thinking might get a little bit better.
- Weeks 8-12: May keep protecting your brain over time.
Good to know
- Only used in science studies
- Keep everything clean and germ-free
Staying safe
- Itchy or stuffy nose
- A small headache
Avoid if you have:
- People who are pregnant or breastfeeding
- People who are allergic to it
Mechanism of action
NAPVSIPQ is the core active motif of ADNP (activity-dependent neuroprotective protein), which binds to microtubules and interacts with tau to maintain cytoskeletal integrity.
Interacts with tubulin and microtubule-associated protein tau, reduces hyperphosphorylation, and promotes neurite outgrowth.
Pharmacodynamics
Neuroprotective effects over weeks; no acute effects.
Potential cognitive protection and mild improvement in animal studies.
Timeline
- Weeks 4-6: Potential subtle cognitive improvement.
- Weeks 8-12: Long-term neuroprotection.
Comparisons
- NAPVSIPQ — effectiveness Emerging, safety Unknown, cost $$$, Medium to use
- Cerebrolysin — effectiveness Moderate, safety Good, cost $$$, Hard to use
Adverse effects
Common:
- Nasal irritation
- Mild headache
Rare:
- Unknown (limited human data)
Contraindications & risk mitigation
Contraindicated in:
- Pregnancy or breastfeeding
- Known hypersensitivity
- Only in research settings
- Use sterile technique
Qué hace
Podría proteger la capacidad de pensar y ayudó un poco a los animales en los estudios.
Cómo funciona
Piensa en este péptido como cinta adhesiva para las células del cerebro dañadas. Ayuda a mantener unida la estructura interna de las células cerebrales que se desmorona en enfermedades como el Alzheimer.
Trabaja con partes pequeñas dentro de las células del cerebro y con una proteína llamada tau. Ayuda a mantener las células sanas y les ayuda a crecer nuevas ramificaciones.
Qué esperar
Protege el cerebro lentamente a lo largo de semanas. No sentirás nada de inmediato.
- Semanas 4-6: Tu capacidad de pensar podría mejorar un poco.
- Semanas 8-12: Podría seguir protegiendo tu cerebro con el tiempo.
Bueno saber
- Solo se usa en estudios científicos
- Mantener todo limpio y libre de gérmenes
Manteniéndose seguro
- Picazón o congestión nasal
- Un dolor de cabeza leve
Evitar si tienes:
- Personas que están embarazadas o en período de lactancia
- Personas que sean alérgicas a este péptido
Mecanismo de acción
NAPVSIPQ es el motivo activo central de ADNP (proteína neuroprotectora dependiente de la actividad), que se une a los microtúbulos e interactúa con la proteína tau para mantener la integridad del citoesqueleto.
Interactúa con la tubulina y la proteína tau asociada a microtúbulos, reduce la hiperfosforilación y promueve el crecimiento de neuritas.
Farmacodinamia
Efectos neuroprotectores a lo largo de semanas; sin efectos agudos.
Protección cognitiva potencial y mejora leve en estudios con animales.
Cronología
- Semanas 4-6: Mejora cognitiva sutil potencial.
- Semanas 8-12: Neuroprotección a largo plazo.
Comparaciones
- NAPVSIPQ — efectividad Emergente, seguridad Desconocida, costo $$$, Media de usar
- Cerebrolysin — efectividad Moderada, seguridad Buena, costo $$$, Difícil de usar
Efectos adversos
Comunes:
- Irritación nasal
- Dolor de cabeza leve
Raros:
- Desconocido (datos humanos limitados)
Contraindicaciones y mitigación de riesgos
Contraindicado en:
- Embarazo o lactancia
- Hipersensibilidad conocida
- Solo en entornos de investigación
- Utilizar técnica estéril
Reference data
Specifications
- Route
- Nasal
- Cycle length
- 30-90 days
FAQ
Common questions
Is NAPVSIPQ the same as davunetide?
Yes, exactly the same octapeptide. Davunetide is the brand name.
Does it work for Alzheimer's?
Animal models show benefit; human trials failed to meet endpoints.
What is the evidence level?
This compound is classified as Anecdotal. Evidence relies primarily on self-reported user experiences. Controlled studies are lacking.
Research
Research & sources
Current evidence for NAPVSIPQ (ADNP fragment) is rated as Anecdotal. No controlled clinical research is available.
- 1. ADNP fragment neuroprotection (2009) — DOI:10.1073/pnas.0905515106
- 2. NAP peptide tau interaction (2011) — DOI:10.1016/j.jmb.2011.03.064
- 3. ADNP fragment neuroprotection (2009)
- 4. NAP peptide tau interaction (2011)