Peptide profile
Selank
Anxiolytic peptide for calm focus and immune support · also known as TP-7, Selanck
Compare Selank with other peptides →Summary
A synthetic heptapeptide derived from the immunomodulatory peptide tuftsin, developed in Russia for anxiolytic and nootropic effects without the sedation or dependence of benzodiazepines.
- Typical dose
- 250-500 mcg per dose, 1-2 times daily
- Half-life
- ~2 minutes (intrinsic); active CNS effects persist 4-6 hours
- Route
- Nasal, Subcutaneous
- Cycle length
- 2-4 weeks
Mechanism
How it works
Modulates GABA-A receptor expression, enhances brain-derived neurotrophic factor (BDNF) expression, and regulates enkephalin degradation, producing anxiolytic and cognitive-enhancing effects.
Reported in research
Benefits
- Reduction of anxiety without sedation
- Improved working memory and attention
- Enhanced stress resilience
- Improved sleep quality and onset
- Immunomodulatory activity (tuftsin-derived)
Context, not a prescription
Dosing
- Typical range
- 250-500 mcg per dose, 1-2 times daily (Nasal, Subcutaneous)
- Cycle length
- 2-4 weeks
- Half-life
- ~2 minutes (intrinsic); active CNS effects persist 4-6 hours
Safety
Side effects & contraindications
Possible side effects
- Mild nasal irritation (intranasal route)
- Transient fatigue
- Vivid dreams
Contraindications
- Known peptide hypersensitivity
- Pregnancy (insufficient data)
Research information, not medical advice. Always consult a licensed clinician before considering any peptide.
In depth
Full profile
What it does
Less worry, clearer thinking, and a balanced body defense team.
How it works
Selank is like a dimmer switch for worry. It turns stress down without turning your lights off. You stay calm and ready to go.
It works on special brain spots that help calm down busy brain signals.
What to expect
You feel calmer in about 30-60 minutes. Better thinking comes in a few days.
- Weeks 1-2: Your mind feels clearer and you feel less stressed.
- Weeks 4-6: You learn and remember things better.
- Weeks 8-12: Your thinking and mood stay steady for a long time.
Good to know
- Use it at bedtime if it makes you sleepy
- Start with a small amount
- Don't drive when you first start
Staying safe
- Feeling a little sleepy at first
- Tickly or sore nose
- Dry mouth
Avoid if you have:
- People who feel very sad (watch them closely)
- Women who are pregnant or feeding a baby
- People taking strong sleep medicines
Mechanism of action
Synthetic analog of tuftsin that influences serotonin, dopamine, and GABA-A receptor modulation.
Modulates GABA-A receptors to increase inhibitory action on neuronal excitability.
Pharmacodynamics
Anxiolytic effects within 30-60 minutes; cognitive benefits within days.
Reduced anxiety, improved cognitive clarity, balanced immune response.
Timeline
- Weeks 1-2: Increased mental clarity and reduced stress.
- Weeks 4-6: Improved learning and memory retention.
- Weeks 8-12: Long-term cognitive and mood stabilization.
Comparisons
- Selank — effectiveness Moderate, safety Good, cost $, Easy to use
- Semax — effectiveness Moderate, safety Good, cost $, Easy to use
Adverse effects
Common:
- Mild drowsiness initially
- Nasal irritation
- Dry mouth
Rare:
- Headache
- Nausea
- Minor fatigue
Contraindications & risk mitigation
Contraindicated in:
- Severe depression (monitor closely)
- Pregnancy or breastfeeding
- Those on strong sedatives
- Take at bedtime if drowsiness occurs
- Start with lower dose
- Avoid driving initially
Qué hace
Menos preocupación, pensamiento más claro y un sistema de defensa corporal equilibrado.
Cómo funciona
Selank es como un regulador de luz para la preocupación. Baja el estrés sin apagar las luces. Te mantienes tranquilo y listo para actuar.
Actúa en zonas específicas del cerebro que ayudan a calmar las señales nerviosas activas.
Qué esperar
Te sentirás más tranquilo en unos 30-60 minutos. La mejora en el pensamiento aparece en unos días.
- Semanas 1-2: Tu mente se siente más clara y experimentas menos estrés.
- Semanas 4-6: Aprendes y recuerdas las cosas con mayor facilidad.
- Semanas 8-12: Tu pensamiento y estado de ánimo se mantienen estables por más tiempo.
Bueno saber
- Úsalo antes de dormir si te da sueño
- Comienza con una cantidad pequeña
- No conduzcas cuando lo empieces a usar
Manteniéndose seguro
- Sensación de sueño leve al principio
- Picazón o molestia nasal
- Boca seca
Evitar si tienes:
- Personas con tristeza muy intensa (requieren supervisión)
- Mujeres embarazadas o en periodo de lactancia
- Personas que toman medicamentos fuertes para dormir
Mecanismo de acción
Análogo sintético de tuftsin que influye en la modulación de receptores de serotonina, dopamina y GABA-A.
Modula los receptores GABA-A para aumentar la acción inhibitoria sobre la excitabilidad neuronal.
Farmacodinamia
Efectos ansiolíticos en 30-60 minutos; beneficios cognitivos en días.
Reducción de la ansiedad, mayor claridad cognitiva, respuesta inmune equilibrada.
Cronología
- Semanas 1-2: Mayor claridad mental y reducción del estrés.
- Semanas 4-6: Mejora del aprendizaje y la retención de memoria.
- Semanas 8-12: Estabilización cognitiva y del estado de ánimo a largo plazo.
Comparaciones
- Selank — efectividad Moderada, seguridad Buena, costo $, Fácil de usar
- Semax — efectividad Moderada, seguridad Buena, costo $, Fácil de usar
Efectos adversos
Comunes:
- Somnolencia leve inicialmente
- Irritación nasal
- Boca seca
Raros:
- Dolor de cabeza
- Náuseas
- Fatiga leve
Contraindicaciones y mitigación de riesgos
Contraindicado en:
- Depresión grave (monitoreo estrecho)
- Embarazo o lactancia
- Personas que toman sedantes potentes
- Tomar al acostarse si aparece somnolencia
- Comenzar con dosis baja
- Evitar conducir inicialmente
Reference data
Specifications
- Molecular formula
- C33H57N7O9
- Molecular weight
- 679.8 g/mol
- Half-life
- ~2 minutes (intrinsic); active CNS effects persist 4-6 hours
- Route
- Nasal, Subcutaneous
- Cycle length
- 2-4 weeks
- Storage
- Lyophilized or solution: refrigerate at 2-8 C. Nasal solution: use within 30 days once opened.
- Legal status
- Approved in Russia as an anxiolytic. Not approved by FDA or EMA; considered a research chemical in most Western countries.
FAQ
Common questions
Is selank addictive like benzodiazepines?
No, it doesn't cause amnesia, withdrawal, or dependence associated with benzodiazepines.
Does selank affect the immune system?
Yes, human trials showed increased anti-inflammatory cytokines in anxiety patients.
What is the evidence level?
This compound is classified as Limited human data. Some human data exists but trials are small, short-term, or not yet replicated.
Research
Research & sources
Current evidence for Selank is rated as Limited human data. Limited human data is available.
- 1. Selank in anxiety disorders (2016) — DOI:10.17116/jnevro201611651123-131
- 2. Tuftsin analogs and anxiety (2015) — DOI:10.1007/s11055-015-0055-1
- 3. Semenova et al. — Selank and anxiety in humans
- 4. Zozulya et al. — Selank as a stable tuftsin analogue
Explore