Peptide profile
SS-31 (Elamipretide)
Mitochondrial peptide for renal protection
Compare SS-31 (Elamipretide) with other peptides →Summary
A tiny protein that helps protect your kidneys and your body's powerhouses.
- Typical dose
- 5-10mg Daily
- Route
- Subcutaneous
- Cycle length
- 30-60 days
- Evidence
- Animal data
Mechanism
How it works
SS-31 acts like a repair kit for kidney cell power plants — it fixes damaged mitochondria that would otherwise fail and cause scarring.
SS-31 targets cardiolipin in mitochondrial inner membranes, reducing ROS and preserving renal tubular function in models of kidney disease.
Reported in research
Benefits
- Helps lower stress and damage inside your kidneys
- Helps guard kidneys from harm caused by diabetes
- Helps your kidney cells' tiny power plants work better
- Helps stop your kidneys from getting stiff and scarred
Context, not a prescription
Dosing
- Typical range
- 5-10mg Daily (Subcutaneous)
- Cycle length
- 30-60 days
Safety
Side effects & contraindications
Possible side effects
- Injection site pain
- Mild nausea
- Temporary fatigue
- Headache
- Dizziness
Contraindications
- Pregnancy or breastfeeding
- Severe mitochondrial disorders (clinical use only)
Research information, not medical advice. Always consult a licensed clinician before considering any peptide.
In depth
Full profile
What it does
Less kidney scarring, better kidney health, and less protein leaking into your pee.
How it works
Think of SS-31 like a repair kit for the kidney cells' power plants. It fixes broken ones before they fail and cause scars.
It goes straight to the tiny power plants in your kidneys. There it protects them from damage.
What to expect
Kidney protection over 4-8 weeks.
- Weeks 2-4: Less stress and damage inside the kidneys.
- Weeks 4-6: The tiny cell power plants work better.
- Weeks 6-8: Less stiffness and scarring in the kidneys.
Good to know
- Start with a smaller amount (5mg)
- Take breaks between cycles
Staying safe
- Soreness where you get the shot
- A little upset tummy
- Feeling tired for a short time
Avoid if you have:
- People who are pregnant or breastfeeding
- People with serious power-plant cell problems (only with a doctor)
Mechanism of action
SS-31 targets cardiolipin in mitochondrial inner membranes, reducing ROS and preserving renal tubular function in models of kidney disease.
Selectively accumulates in kidney mitochondria, protecting cardiolipin from oxidative damage.
Pharmacodynamics
Renal protection over 4-8 weeks.
Reduced renal fibrosis, improved kidney function markers, less proteinuria.
Timeline
- Weeks 2-4: Reduced oxidative stress markers.
- Weeks 4-6: Improved mitochondrial function.
- Weeks 6-8: Reduced renal fibrosis.
Comparisons
- SS-31 — effectiveness Emerging, safety Good, cost $$$, Medium to use
- ARA-290 — effectiveness Emerging, safety Good, cost $$$, Medium to use
Adverse effects
Common:
- Injection site pain
- Mild nausea
- Temporary fatigue
Rare:
- Headache
- Dizziness
Contraindications & risk mitigation
Contraindicated in:
- Pregnancy or breastfeeding
- Severe mitochondrial disorders (clinical use only)
- Start with lower dose (5mg)
- Cycle with breaks
Qué hace
Menos cicatrices en los riñones, mejor salud renal y menos proteínas que se filtran en tu orina.
Cómo funciona
Piensa en SS-31 como un kit de reparación para las centrales de energía de las células renales. Repara las averiadas antes de que fallen y causen cicatrices.
Va directamente a las pequeñas centrales de energía de tus riñones. Allí las protege del daño.
Qué esperar
Protección renal en 4-8 semanas.
- Semanas 2-4: Menos estrés y daño dentro de los riñones.
- Semanas 4-6: Las pequeñas centrales de energía celular funcionan mejor.
- Semanas 6-8: Menos rigidez y cicatrices en los riñones.
Bueno saber
- Comenzar con una cantidad más pequeña (5 mg)
- Tomar descansos entre los ciclos
Manteniéndose seguro
- Molestias en el lugar de la inyección
- Un poco de malestar estomacal
- Sentirse cansado por un corto tiempo
Evitar si tienes:
- Personas que están embarazadas o en período de lactancia
- Personas con problemas graves en las centrales de energía celular (solo con un médico)
Mecanismo de acción
SS-31 se dirige a la cardiolipina en las membranas mitocondriales internas, reduciendo ROS y preservando la función tubular renal en modelos de enfermedad renal.
Se acumula selectivamente en las mitocondrias renales, protegiendo la cardiolipina del daño oxidativo.
Farmacodinamia
Protección renal en 4-8 semanas.
Reducción de la fibrosis renal, mejora de los marcadores de función renal y menor proteinuria.
Cronología
- Semanas 2-4: Reducción de marcadores de estrés oxidativo.
- Semanas 4-6: Mejora de la función mitocondrial.
- Semanas 6-8: Reducción de la fibrosis renal.
Comparaciones
- SS-31 — efectividad Emergente, seguridad Buena, costo $$$, Media de usar
- ARA-290 — efectividad Emergente, seguridad Buena, costo $$$, Media de usar
Efectos adversos
Comunes:
- Dolor en el sitio de inyección
- Náuseas leves
- Fatiga temporal
Raros:
- Dolor de cabeza
- Mareos
Contraindicaciones y mitigación de riesgos
Contraindicado en:
- Embarazo o lactancia
- Trastornos mitocondriales graves (solo uso clínico)
- Comenzar con dosis más baja (5 mg)
- Realizar ciclos con descansos
Reference data
Specifications
- Route
- Subcutaneous
- Cycle length
- 30-60 days
FAQ
Common questions
Is SS-31 effective for chronic kidney disease?
Animal studies show benefit in diabetic nephropathy and toxin-induced injury; human trials ongoing.
What is the evidence level?
This compound is classified as Animal data. Most data comes from preclinical animal studies. Human clinical trial evidence is limited or absent.
Research
Research & sources
Current evidence for SS-31 (Elamipretide) is rated as Animal data. Research is based primarily on animal models.
- 1. SS-31 in kidney disease (2014) — DOI:10.1681/ASN.2013040419
- 2. Mitochondrial peptides in nephrology (2017) — DOI:10.1016/j.kint.2017.03.034
- 3. SS-31 in kidney disease (2014)
- 4. Mitochondrial peptides in nephrology (2017)