Peptide profile
SS-31 (Elamipretide)
Mitochondrial peptide for metabolic and renal health
Compare SS-31 (Elamipretide) with other peptides →Summary
A tiny protein that helps your cells' power makers and protects your body and kidneys.
- Typical dose
- 5-10mg Daily
- Route
- Subcutaneous
- Cycle length
- 30-60 days
- Evidence
- Animal data
Mechanism
How it works
SS-31 acts like a maintenance crew for your cellular power plants — it repairs mitochondria so they generate energy efficiently.
SS-31 is a tetrapeptide targeting cardiolipin in the inner mitochondrial membrane, stabilizing electron transport chain complexes and reducing ROS.
Reported in research
Benefits
- Protects cell power makers from damage
- Helps cells make more energy
- Protects kidneys from harm
- Helps your body use energy better
Context, not a prescription
Dosing
- Typical range
- 5-10mg Daily (Subcutaneous)
- Cycle length
- 30-60 days
Safety
Side effects & contraindications
Possible side effects
- Injection site pain
- Mild nausea
- Temporary fatigue
- Headache
- Dizziness
- Flushing
Contraindications
- Pregnancy or breastfeeding
- Severe mitochondrial disorders (clinical use only)
Research information, not medical advice. Always consult a licensed clinician before considering any peptide.
In depth
Full profile
What it does
Less tiredness, more stamina, and a healthier body.
How it works
SS-31 is like a repair crew for your cells' tiny power plants. It fixes them so they make energy well.
It goes straight to your cells' power makers and protects them from damage.
What to expect
More energy in 2-3 weeks. Better body health by 4-6 weeks.
- Weeks 1-2: You feel less tired and have more energy.
- Weeks 3-4: You can stay active for longer.
- Weeks 6-8: Your cell power makers work better.
Good to know
- Start with a smaller dose (5mg)
- Take breaks between cycles
- Watch how your energy feels
Staying safe
- Sore spot where you inject
- A little upset stomach
- Feeling tired for a short time
Avoid if you have:
- People who are pregnant or breastfeeding
- People with serious cell power maker problems (only with a doctor)
Mechanism of action
SS-31 is a tetrapeptide targeting cardiolipin in the inner mitochondrial membrane, stabilizing electron transport chain complexes and reducing ROS.
Selectively accumulates in mitochondria, protecting cardiolipin from oxidative damage.
Pharmacodynamics
Energy improvements within 2-3 weeks; metabolic benefits by 4-6 weeks.
Reduced fatigue, improved physical endurance, better metabolic health.
Timeline
- Weeks 1-2: Reduced fatigue and improved energy.
- Weeks 3-4: Enhanced physical endurance.
- Weeks 6-8: Improved mitochondrial function.
Comparisons
- SS-31 — effectiveness Emerging, safety Good, cost $$$, Medium to use
- MOTS-c — effectiveness Emerging, safety Emerging, cost $$, Medium to use
Adverse effects
Common:
- Injection site pain
- Mild nausea
- Temporary fatigue
Rare:
- Headache
- Dizziness
- Flushing
Contraindications & risk mitigation
Contraindicated in:
- Pregnancy or breastfeeding
- Severe mitochondrial disorders (clinical use only)
- Start with lower dose (5mg)
- Cycle with breaks
- Monitor energy levels
Qué hace
Menos cansancio, más resistencia y un cuerpo más saludable.
Cómo funciona
SS-31 es como un equipo de reparación para las pequeñas centrales de energía de tus células. Las arregla para que produzcan energía correctamente.
Va directamente a las fábricas de energía de tus células y las protege del daño.
Qué esperar
Más energía en 2-3 semanas. Mejor salud corporal en 4-6 semanas.
- Semanas 1-2: Te sentirás menos cansado y tendrás más energía.
- Semanas 3-4: Podrás mantenerte activo por más tiempo.
- Semanas 6-8: Las fábricas de energía de tus células funcionarán mejor.
Bueno saber
- Comenzar con una dosis más pequeña (5 mg)
- Tomar descansos entre ciclos
- Observar cómo se siente tu energía
Manteniéndose seguro
- Dolor en el lugar de la inyección
- Un poco de malestar estomacal
- Sentirse cansado por un corto tiempo
Evitar si tienes:
- Personas que están embarazadas o en periodo de lactancia
- Personas con problemas graves en las fábricas de energía de sus células (solo con un médico)
Mecanismo de acción
SS-31 es un tetrapéptido que se dirige a la cardiolipina en la membrana mitocondrial interna, estabilizando los complejos de la cadena de transporte de electrones y reduciendo las ROS.
Se acumula selectivamente en las mitocondrias, protegiendo la cardiolipina del daño oxidativo.
Farmacodinamia
Mejoras en la energía en 2-3 semanas; beneficios metabólicos a las 4-6 semanas.
Menor fatiga, mejor resistencia física, mejor salud metabólica.
Cronología
- Semanas 1-2: Menor fatiga y energía mejorada.
- Semanas 3-4: Mayor resistencia física.
- Semanas 6-8: Función mitocondrial mejorada.
Comparaciones
- SS-31 — efectividad Emergente, seguridad Buena, costo $$$, Media de usar
- MOTS-c — efectividad Emergente, seguridad Emergente, costo $$, Media de usar
Efectos adversos
Comunes:
- Dolor en el sitio de inyección
- Náuseas leves
- Fatiga temporal
Raros:
- Dolor de cabeza
- Mareos
- Enrojecimiento
Contraindicaciones y mitigación de riesgos
Contraindicado en:
- Embarazo o lactancia
- Trastornos mitocondriales graves (solo uso clínico)
- Comenzar con dosis más baja (5 mg)
- Realizar ciclos con descansos
- Monitorear los niveles de energía
Reference data
Specifications
- Route
- Subcutaneous
- Cycle length
- 30-60 days
FAQ
Common questions
Is SS-31 FDA-approved?
No, it is in clinical trials for mitochondrial diseases but not yet approved.
What is the evidence level?
This compound is classified as Animal data. Most data comes from preclinical animal studies. Human clinical trial evidence is limited or absent.
Research
Research & sources
Current evidence for SS-31 (Elamipretide) is rated as Animal data. Research is based primarily on animal models.
- 1. SS-31 in mitochondrial disease (2019) — DOI:10.1016/j.ebiom.2019.05.043
- 2. Cardiolipin targeting therapy (2017) — DOI:10.1124/pr.116.013508
- 3. SS-31 in mitochondrial disease (2019)
- 4. Cardiolipin targeting therapy (2017)