Peptide profile
TGF-β1 Mimetic Peptide (Tetrapeptide-28)
Tetrapeptide-28 for scarless healing
Compare TGF-β1 Mimetic Peptide (Tetrapeptide-28) with other peptides →Summary
A tiny protein that copies a body signal to make smaller scars.
- Typical dose
- 0.5-2% concentration 2x daily on healing wound
- Route
- Topical
- Cycle length
- Until healed + 2 weeks
- Evidence
- Anecdotal
Mechanism
How it works
This peptide acts like a scar prevention coach — it tells healing wounds to lay down collagen in neat rows like a woven fabric, not a tangled knot (scar).
Tetrapeptide-28 is a synthetic heptapeptide that mimics TGF-β1's anti-fibrotic activity, promoting organized (not scar) collagen alignment.
Reported in research
Benefits
- Helps make smaller scars
- Helps skin rebuild in neat, even rows
- Helps wounds close faster
- Calms swelling while skin heals
Context, not a prescription
Dosing
- Typical range
- 0.5-2% concentration 2x daily on healing wound (Topical)
- Cycle length
- Until healed + 2 weeks
Safety
Side effects & contraindications
Possible side effects
- Minimal irritation
- Mild redness
- Contact dermatitis
Contraindications
- Open infected wounds
- Known peptide sensitivity
Research information, not medical advice. Always consult a licensed clinician before considering any peptide.
In depth
Full profile
What it does
Smaller scars, faster healing, and marks that are harder to see.
How it works
Think of this peptide like a coach for healing skin. It tells the skin to build in neat rows, like woven cloth. That way you get smooth skin, not a tangled knot scar.
It connects to special spots on skin-building cells. This helps the skin rebuild in neat, even rows.
What to expect
You can see smaller scars in about 4 to 8 weeks.
- Weeks 1-2: Wounds close faster.
- Weeks 3-4: Less redness and fewer bumps.
- Weeks 6-8: The scar looks lighter and flatter.
Good to know
- Do not put it on deep wounds that have an infection.
Staying safe
- A tiny bit of irritation
- A little redness
Avoid if you have:
- People with open, infected wounds
- People who react badly to peptides
Mechanism of action
Tetrapeptide-28 is a synthetic heptapeptide that mimics TGF-β1's anti-fibrotic activity, promoting organized (not scar) collagen alignment.
Binds to TGF-β receptors on fibroblasts, reducing myofibroblast differentiation and promoting organized ECM deposition.
Pharmacodynamics
Visible scar reduction at 4-8 weeks.
Reduced scar formation, faster healing, less visible marks.
Timeline
- Weeks 1-2: Faster wound closure.
- Weeks 3-4: Reduced redness and bumpiness.
- Weeks 6-8: Fainter, flatter scar.
Comparisons
- TGF-β Mimetic Peptide — effectiveness Emerging, safety Emerging, cost $$, Medium to use
- Silicone Gel — effectiveness Moderate, safety Excellent, cost $$, Easy to use
Adverse effects
Common:
- Minimal irritation
- Mild redness
Rare:
- Contact dermatitis
Contraindications & risk mitigation
Contraindicated in:
- Open infected wounds
- Known peptide sensitivity
- Do not apply to deep infected wounds
Qué hace
Cicatrices más pequeñas, curación más rápida y marcas más difíciles de ver.
Cómo funciona
Piensa en este péptido como un entrenador para la piel en curación. Le indica a la piel que se construya en filas ordenadas, como una tela tejida. Así obtienes piel suave, en lugar de una cicatriz en forma de nudo enredado.
Se conecta a puntos especiales en las células que construyen la piel. Esto ayuda a que la piel se regenere en filas ordenadas y uniformes.
Qué esperar
Puedes ver cicatrices más pequeñas en aproximadamente 4 a 8 semanas.
- Semanas 1-2: Las heridas cierran más rápido.
- Semanas 3-4: Menos enrojecimiento y menos bultos.
- Semanas 6-8: La cicatriz se ve más clara y plana.
Bueno saber
- No lo apliques en heridas profundas que estén infectadas.
Manteniéndose seguro
- Un poco de irritación
- Un poco de enrojecimiento
Evitar si tienes:
- Personas con heridas abiertas e infectadas
- Personas que reaccionan mal a los péptidos
Mecanismo de acción
Tetrapeptide-28 es un heptapéptido sintético que imita la actividad antifibrótica del TGF-β1, promoviendo una alineación del colágeno organizada (sin formación de cicatrices).
Se une a los receptores de TGF-β en los fibroblastos, reduciendo la diferenciación de miofibroblastos y promoviendo la deposición organizada de la matriz extracelular.
Farmacodinamia
Reducción visible de cicatrices en 4-8 semanas.
Reducción en la formación de cicatrices, curación más rápida y marcas menos visibles.
Cronología
- Semanas 1-2: Cierre más rápido de la herida.
- Semanas 3-4: Reducción del enrojecimiento y la irregularidad.
- Semanas 6-8: Cicatriz más tenue y plana.
Comparaciones
- Péptido Mímético de TGF-β — efectividad Emergente, seguridad Emergente, costo $$, Media de usar
- Gel de Silicona — efectividad Moderada, seguridad Excelente, costo $$, Fácil de usar
Efectos adversos
Comunes:
- Irritación mínima
- Enrojecimiento leve
Raros:
- Dermatitis de contacto
Contraindicaciones y mitigación de riesgos
Contraindicado en:
- Heridas abiertas e infectadas
- Sensibilidad conocida a péptidos
- No aplicar en heridas profundas e infectadas
Reference data
Specifications
- Route
- Topical
- Cycle length
- Until healed + 2 weeks
FAQ
Common questions
Can it remove old scars?
Less effective on mature scars; best used on fresh wounds.
How is it different from silicone gel?
Silicone hydrates and protects; this peptide actively modulates collagen organization.
What is the evidence level?
This compound is classified as Anecdotal. Evidence relies primarily on self-reported user experiences. Controlled studies are lacking.
Research
Research & sources
Current evidence for TGF-β1 Mimetic Peptide (Tetrapeptide-28) is rated as Anecdotal. No controlled clinical research is available.
- 1. TGF-β peptide for scars (2010) — DOI:10.1111/j.1524-4725.2010.01734.x
- 2. Peptide scar therapy (2019) — DOI:10.1111/jocd.12842
- 3. TGF-β peptide for scars (2010)
- 4. Peptide scar therapy (2019)